They can result from irritations such as an illfitting denture or the habit of chewing on the inside of the cheek. Leukoplakia definitionpage contents1 leukoplakia definition2 leukoplakia types3 what is homogeneous leukoplakia. Carcinoma in situ of the oral cavity intraepithelial carcinoma nicotine stomatitis. Leukoplakia, precancerous tumour of the mucous membranes, usually seen in the mouth or on the tongue or cheeks, but also known to occur on the lips, as well as on the vagina, vulva, or anus. The pooled estimated prevalence rate of oral leukoplakia in 2003 varied between 1. Plakiapatch oral leukoplakia is defined by the who as a white patch or plaque that cannot be scrapped off and also characterized clinically or pathologically as any other disease. However, some patients may complain of a burning sensation and.
Leukoplakia are patches on the tongue, in the mouth, or on the inside of the cheek. Leukoplakia is primarily a disorder of the mucous membranes of the mouth. Leukoplakia genetic and rare diseases information center. What is leukoplakia and why is it the american academy. Oral leukoplakia is a potentially malignant disorder affecting the oral mucosa. In general, the term leukoplakia implies only the clinical feature of a persistent. Leukoplakia, management, surgical, nonsurgical treatment, introduction oral leukoplakia ol is the most frequent precancerous lesion of the oral cavity. Leukoplakia definition of leukoplakia by medical dictionary. Soames and southam reported mutations of p53 in the cells from dysplastic areas of some leukoplakias who smoke and drink heavily. Leukoplakia is a discomforting condition that affects around 3% of the world population. The most frequent location for leukoplakia was the buccal mucosa 28.
Oral leukoplakia tsvetanov ts1 abstract oral leukoplakia is defined as a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion. Therefore, a process of exclusion establishes the diagnosis of the disease. Leukoplakia causes, pictures, symptoms, treatment, prognosis. Pdf zusammenfugen pdfdateien online kostenlos zu kombinieren. Leukoplakia generally refers to a firmly attached white patch on a mucous membrane which is associated with an increased. Oral leukoplakia describes a white patch or plaque of the oral mucosa that cannot be characterised clinically or pathologically as any other disease. This is a disorder which is most generally found in the elderly. The aim of this paper was to assess the nonsurgical treatment of oral leukoplakia ol. Leukoplakia of the urinary tract radiology reference.
Kanmani2, n megalai3 1department of oral medicine and radiology, indira gandhi institute of dental sciences, pondicherry, india. Leukoplakia definition of leukoplakia by merriamwebster. Risk factors include all forms of tobacco use forms including cigar, cigarette. Dieses kostenlose tool erlaubt es mehrere pdfs oder bilddateien miteinander zu einem pdfdokument zu verbinden. Oral leukoplakia ol is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. A white patch or plaque that cannot be characterized clinically or pathologically as any other disease. Note on the merge of two maximum models under same constraints. Oral erythroplasia is rare, but its malignant transformation rate is the highest among all of the precancerous lesions in the mouth. Proliferative verrucous leukoplakia is a diffuse white andor papillary lesion seen in older patients, often associated with human papilloma viruses, which has an inexorably slow progression over one or two decades, to verrucous or squamous cell carcinoma candidal leukoplakias may be associated with an increased risk of malignant change ch. Moreover, it may be hyperkeratotic in nature, meaning there is hypertrophy or.
Clinical presentation clinically the condition presents with hematuria in onethird of cases, dysuria, frequency and nocturia, and thus it can mimic. Pdf zusammenfugen online pdf dateien zusammenfugen. Pdfdateien in einzelne seiten aufteilen, seiten loschen oder drehen, pdfdateien einfach zusammenfugen oder. While most cases of leukoplakia may not be considered as dangerous and may disappear on its own, there is always the risk of the more serious cases developing into oral cancer.
Not all white patches are called leukoplakia just the ones that cannot be rubbed off and cannot be diagnosed as any other condition or disease figures 14. Leukoplakia is a firmly attached white patch on a mucous membrane which is associated with an increased risk of cancer. In 1978, oral leukoplakia has been defined by the world health organization who as. One oral problem that many people may not be too familiar with but can be potentially serious is oral leukoplakia. Leukoplakia appears as thick, white patches on the inside surfaces of your mouth. An abnormal condition characterized by white spots or patches on mucous membranes, especially of the mouth and vulva. It is defined as essentially an oral mucosal white lesion that cannot be considered as any other definable lesion. Leukoplakia is a condition wherein white or gray patches appear in some parts of the mouth, predominantly in the buccal mucosa and the tongue. Although one type of leukoplakia speckled leukoplakia carries a higher risk ofdevelopinginto malignancy than the other homogenous leukoplakia, the clinican must be equally aware of these lesions. It can also be a sign of precancerous changes in the mouth or mouth cancer.
Leukoplasia definition of leukoplasia by medical dictionary. Oral leukoplakia may later prove to be due to one of the following conditions. Leukoplakia of the urinary tract is a squamous metaplasia of the urothelium keratinization. Pdf note on the merge of two maximum models under same. A type of leukoplakia of the mouth, called oral hairy leukoplakia, is caused by the epsteinbarr virus. Hairy leukoplakia is a condition that is characterised by irregular white patches on the side of the tongue and occasionally elsewhere on the tongue or in the mouth. The edges of the lesion are typically abrupt and the lesion changes with time. Occasionally, leukoplakia patches develop on the female external genitalia.
Some leukoplakias arise within fields of precancerized oral. Leukoplakia has various appearances and changes can usually develop on the gums, the inside of cheeks, and the bottom of the mouth as well as often on the tongue and can also appear as. Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Leukoplakia buccalis definition of leukoplakia buccalis. Leukoplakia is a condition in which thick, white or grayish patches form usually inside your mouth. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. However, leukoplakia is not limited as an oral disorder alone, as it may also appear in the genital area of the female. Leukoplakia affects the mucous membranes of the mouth. Although the sores can vary in appearance, they are usually white or gray. Leukoplakia is the most common potentially malignant lesion of the oral cavity and can be categorised according to its clinical appearance as homogeneous or nonhomogenous. Discussion in this study the prevalence of leukoplakia in a selected population was 2. Leukoplakia pictures, causes, symptoms, treatment and. It has a number of possible causes, including repeated injury or irritation.
With leukoplakia lookohplaykeyuh, thickened, white patches form on your gums, the insides of your cheeks. The sores can vary in appearance but are typically white or gray, and have thick, raised edges with a hard surface. In an explanatory note it has been explicitly stated that the term leukoplakia is unrelated to the absence or. Leukoplakia is a precancerous lesion that develops on the tongue or the inside of the cheek as a response to chronic irritation. The growth can occur at any time in your life, but it is most common in the elderly. Proliferative verrucous leukoplakia pvl is a rare form of oral leukoplakia, which was first described in 1985 by hansen et al. Grayish or white patches which can not be wiped away. It is a form of leukoplakia, which refers to white patches on the mucous membranes of the mouth often arising in response to chronic irritation. But other irritants can cause this condition as well. Leukoplakia patches can also develop on the female genital area. Tobacco and areca nut use, either alone or in combination are the most common risk factors for oral leukoplakia, but some oral leukoplakias are idiopathic. The main purpose of oral leukoplakia management is to avoid malignant transformation of the lesion or if this happened to detect this in early stages. It usually occurs within the mouth, although sometimes mucosa in other parts of the gastrointestinal tract, urinary. Hairy leukoplakia is a type of leukoplakia caused by the epsteinbarr virus.
Epidemiological and clinicopathological study of oral. Read and know what is leukoplakia as well as all about its causes, symptoms, diagnosis, treatment and prevention. Leukoplakia luke o plake ee ah is a clinical term that is used to describe certain white patches in the mouth. Leukoplakia are thick, whitishcolor patches that form on the inside of the cheeks, gums or tongue, these patches are caused by excess cell growth and are common among tobacco users.
Leukoplakia first appears as a small, smooth, white spot that cannot be scraped off but develops into a larger area of thickening with a rough texture and colour varying from white to gray. It often affects people with a weakened immune system, particularly those with hiv and aids or who have had an organ transplant and are taking immunosuppressant medication it causes fuzzy white patches, often on the sides of the tongue, that look folded or ridged. Most patches of leukoplakia are benign, but a small number can show early cancer symptoms, and numerous mouth cancers develop beside the areas of leukoplakia. Ol is premalignant and is associated with squamous cell carcinoma scc. Hairy leukoplakia of the mouth is an unusual form of leukoplakia that is seen only in people who are infected with hiv, have aids, or aidsrelated complex. For this estimated rate, the author stefano petti, in a metaanalysis including 23 primary studies from all over the world published in the period 19862002 found no difference between geographical areas and between younger and older patients. Since then, various published case series have presented pvl as a.
An overview of oral leukoplakia cosmo dental centre. Learn more from webmd about how leukoplakia is treated. Leukoplakia is a condition in which thick, white patches or lesions appear within the mouth typically on the gums or inside the cheeks and is caused by excess cell growth. Oral leukoplakia ol is the most frequent potentially malignant disorder of oral mucosa.
Leukoplakia, or white and gray patches inside the mouth, may be caused by irritation. Leukoplakia definition is an abnormal condition in which thickened white patches of epithelium occur on the mucous membranes as of the mouth or vulva. The primary outcomes of interest were clinical resolution, malignant transformation, followup, and recurrence of ol. Oral leukoplakia ol is a white patch or plaque of the oral mucosa that cannot be characterised clinically or pathologically as any other condition such as cheek biting, candidosis, lichen planus and materia alba. Therefore, it is advised to see the dentist if an individual has persistent, unusual changes in the mouth. Leukoplakia is typically not hazardous, but it often can be serious. Oral leukoplakia is a white patch or plaque that develops in the oral cavity and is strongly associated with smoking. Leukoplakia precancerous lesion inside of the cheek. This function is accomplished through a ligation between betacarotene and oxygen, which is an unstable reactive molecule, thus diminishing the damaging effects of free radicals lycopene in vitro experiments have shown the inhibition of the process of human neoplastic cellular growth by lycopene, since this.
896 841 466 1291 520 986 1200 1142 539 696 1205 453 1064 1424 901 844 109 1554 1339 1033 170 1312 372 142 1070 1475 603 1071 705 207 883 160 1028 1147 735 249 1263 786 936 397 2 599 1389 1070 880